The molecular elements that underlie developmental evolution

Alonso, Claudio R and Wilkins, Adam S (2005) The molecular elements that underlie developmental evolution. Nature Reviews Genetics, 6. pp. 709-715. ISSN 1471-0064

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Abundant evidence indicates that developmental evolution, the foundation of morphological evolution, is based on changes in gene function. Over the past decade a consensus has developed that transcriptional regulation, acting through enhancer sequences, is the primary level of evolutionary significant change. Here we propose that other regulatory levels are probably as important as enhancers in developmental evolution. We also explain why these alternative regulatory levels might have been neglected, and briefly discuss ways to test our hypothesis.

Item Type: Article
Additional Information: In this work I have conceived a new theoretical framework to investigate the mechanisms of developmental evolution. I initiated the research question, i.e. what is the spectrum of molecular modules underlying developmental evolution? - collected all data to address the question, co-analysed the data and co-wrote the paper.
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Claudio Alonso
Date Deposited: 06 Feb 2012 19:32
Last Modified: 20 Mar 2012 16:18
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