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The dynein-tubulin motor powers active oscillations and amplification in the hearing organ of the mosquito

journal contribution
posted on 2023-06-07, 23:14 authored by Ben Warren, Andrei N Lukashkin, Ian J Russell
The design principles and specific proteins of the dynein¿tubulin motor, which powers the flagella and cilia of eukaryotes, have been conserved throughout the evolution of life from algae to humans. Cilia and flagella can support both motile and sensory functions independently, or sometimes in parallel to each other. In this paper we show that this dual sensory¿motile role of eukaryotic cilia is preserved in the most sensitive of all invertebrate hearing organs, the Johnston's organ of the mosquito. The Johnston's organ displays spontaneous oscillations, which have been identified as being a characteristic of amplification in the ears of mosquitoes and Drosophila. In the auditory organs of Drosophila and vertebrates, the molecular basis of amplification has been attributed to the gating and adaptation of the mechanoelectrical transducer channels themselves. On the basis of their temperature-dependence and sensitivity to colchicine, we attribute the molecular basis of spontaneous oscillations by the Johnston's organ of the mosquito Culex quinquefasciatus, to the dynein¿tubulin motor of the ciliated sensillae. If, as has been claimed for insect and vertebrate hearing organs, spontaneous oscillations epitomize amplification, then in the mosquito ear, this process is independent of mechanotransduction.

History

Publication status

  • Published

Journal

Proceedings B: Biological Sciences

ISSN

1471-2954

Publisher

Royal Society, The

Volume

277

Page range

1761-1769

Pages

9.0

Department affiliated with

  • Biology and Environmental Science Publications

Notes

Issue No. 1688

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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