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The compositional evolution of the murid genome

journal contribution
posted on 2023-06-07, 23:12 authored by Nick G C Smith, Adam Eyre-WalkerAdam Eyre-Walker
Murid rodents show much less variation in isochore base composition than do most other mammals, a difference which has been referred to as the murid shift. We have investigated the murid shift by asking (1) whether the murid shift is ongoing and (2) whether there is any evidence of selection or biased gene conversion affecting base composition in the present-day mouse genome. By estimating the ancestral base composition of protein-coding genes in murids we can confirm that the murid shift is ongoing. Tests using nongenic polymorphism data fail to reject the hypothesis that base composition is due to mutation bias alone. However, the patterns of compositional change suggested by the polymorphism and divergence data differ, suggesting the possibility of two murid shifts.

History

Publication status

  • Published

Journal

Journal of Molecular Evolution

ISSN

0022-2844

Issue

2

Volume

55

Page range

197-201

Pages

5.0

Department affiliated with

  • Evolution, Behaviour and Environment Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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