Timsit, Youri and Varnai, Peter (2011) Cytosine, the double helix and DNA self-assembly. Journal of Molecular Recognition, 24 (2). pp. 137-138.
Full text not available from this repository.Abstract
DNA self-assembly has crucial implications in reading out the genetic information in the cell and in nanotechnological applications. In a recent paper, self-assembled DNA crystals displaying spectacular triangular motifs have been described (Zheng et al., 2009). The authors claimed that their data demonstrate the possibility to rationally design well-ordered macromolecular 3D DNA lattice with precise spatial control using sticky ends. However, the authors did not recognize the fundamental features that control DNA self-assembly in the lateral direction. By analysing available crystallographic data and simulating a DNA triangle, we show that the double helix geometry, sequence-specific cytosinephosphate interactions and divalent cations are in fact responsible for the precise spatial assembly of DNA.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Depositing User: | Peter Varnai |
Date Deposited: | 06 Feb 2012 19:31 |
Last Modified: | 01 Mar 2012 11:51 |
URI: | http://sro.sussex.ac.uk/id/eprint/21021 |