Timsit, Youri and Varnai, Peter (2011) Cytosine, the double helix and DNA self-assembly. Journal of Molecular Recognition, 24 (2). pp. 137-138.

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Abstract

DNA self-assembly has crucial implications in reading out the genetic information in the cell and in nanotechnological applications. In a recent paper, self-assembled DNA crystals displaying spectacular triangular motifs have been described (Zheng et al., 2009). The authors claimed that their data demonstrate the possibility to rationally design well-ordered macromolecular 3D DNA lattice with precise spatial control using sticky ends. However, the authors did not recognize the fundamental features that control DNA self-assembly in the lateral direction. By analysing available crystallographic data and simulating a DNA triangle, we show that the double helix geometry, sequence-specific cytosinephosphate interactions and divalent cations are in fact responsible for the precise spatial assembly of DNA.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
Depositing User:	Peter Varnai
Date Deposited:	06 Feb 2012 19:31
Last Modified:	01 Mar 2012 11:51
URI:	http://sro.sussex.ac.uk/id/eprint/21021

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