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Cytosine, the double helix and DNA self-assembly

journal contribution
posted on 2023-06-07, 23:12 authored by Youri Timsit, Peter Varnai
DNA self-assembly has crucial implications in reading out the genetic information in the cell and in nanotechnological applications. In a recent paper, self-assembled DNA crystals displaying spectacular triangular motifs have been described (Zheng et al., 2009). The authors claimed that their data demonstrate the possibility to rationally design well-ordered macromolecular 3D DNA lattice with precise spatial control using sticky ends. However, the authors did not recognize the fundamental features that control DNA self-assembly in the lateral direction. By analysing available crystallographic data and simulating a DNA triangle, we show that the double helix geometry, sequence-specific cytosinephosphate interactions and divalent cations are in fact responsible for the precise spatial assembly of DNA.

History

Publication status

  • Published

Journal

Journal of Molecular Recognition

Issue

2

Volume

24

Page range

137-138

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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