Synonymous substitutions are clustered in enterobacterial genes

Eyre-Walker, Adam (1994) Synonymous substitutions are clustered in enterobacterial genes. Journal of Molecular Evolution, 39 (5). pp. 448-451. ISSN 0022-2844

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The spatial distribution of synonymous substitutions in enterobacterial genes is investigated. It is shown that synonymous substitutions are significantly clustered in such a way that a synonymous substitution in one codon elevates the rate of synonymous substitution in an adjacent codon by about 10%. The level of clustering does not appear to be related to the level of gene expression, and it is restricted to a range of two or three codons. There are at least three possible explanations: (1) sequence-directed mutagenesis, (2) recombination, and (3) selection.

Item Type: Article
Schools and Departments: School of Life Sciences > Evolution, Behaviour and Environment
Depositing User: Adam Eyre-Walker
Date Deposited: 06 Feb 2012 19:24
Last Modified: 01 May 2012 15:30
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