Tools
Tools
Sánchez-Herrero, Ernesto, Couso, Juan Pablo, Capdevila, Javier and Guerrero, Isabel (2000) The fu gene discriminates between pathways to control dpp expression in Drosophila imaginal discs. Mechanisms of Development, 55 (2). pp. 159-170. ISSN 09254773
Full text not available from this repository.Abstract
The genes decapentaplegic (dpp) and wingless (wg), which encode secreted factors of the TGF-ß and Wnt families, respectively, are required for the proper development of the imaginai discs. The expression of these genes must be finely regulated since their ectopic expression induces overgrowth and pattern alterations in wings and legs. Genes like patched (ptc) and costal-2 (cos-2), and the gene encoding the catalytic subunit of the protein kinase A gene (pkA) are required to restrict dpp and wg expression in their proper positions. We show here that some mutations in the cubitus interrupts (ci) gene also show ectopic dpp expression in the wing disc. We have also analyzed the functional hierarchy between these genes and the gene fused (FU), in the activation of dpp by the hedgehog (hh) signal. fu is required to transmit the hh signal in imaginai discs, since fu mutations rescue the phenotype due to the ectopic hh expression or to the lack of ptc activity. fu is also required for the activation of engrailed (en) caused when hh is ectopically activated in the wing disc. By contrast, fu mutations do not rescue the phenotypic consequences of the abnormal ci, cos-2 or pkA activity. Although fu, cos-2 and ci probably form part of the same pathway that controls dpp expression, pkA probably controls dpp transcription by a different pathway.
| Item Type: | Article |
|---|---|
| Additional Information: | Describes the roles of the fused kinase in hedhehog signalling |
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine School of Life Sciences > Biochemistry |
| Depositing User: | Juan Couso |
| Date Deposited: | 06 Feb 2012 19:21 |
| Last Modified: | 06 Jun 2019 09:08 |
| URI: | http://sro.sussex.ac.uk/id/eprint/20217 |