Gorelik, Julia, Shevchuk, Andrew I, Frolenkov, Gregory I, Diakonov, Ivan A, Lab, Max J, Kros, Corné J, Richardson, Guy P, Vodyanoy, Igor, Edwards, Christopher R W, Klenerman, David and Korchev, Yuri E (2003) Dynamic assembly of surface structure in living cells. Proceedings of the National Academy of Sciences, 100 (10). ISSN 0027-8424

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Abstract

Although the dynamics of cell membranes and associated structures is vital for cell function, little is known due to lack of suitable methods. We found, using scanning ion conductance microscopy, that microvilli, membrane projections supported by internal actin bundles, undergo a life cycle: fast height-dependent growth, relatively short steady state, and slow height-independent retraction. The microvilli can aggregate into relatively stable structures where the steady state is extended. We suggest that the intrinsic dynamics of microvilli, combined with their ability to make stable structures, allows them to act as elementary ¿building blocks¿ for the assembly of specialized structures on the cell surface.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Neuroscience
Depositing User:	Corne Kros
Date Deposited:	06 Feb 2012 19:21
Last Modified:	21 May 2012 15:36
URI:	http://sro.sussex.ac.uk/id/eprint/20216

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