File(s) not publicly available
A reanalysis of the indirect evidence for recombination in human mitochondrial DNA.
journal contribution
posted on 2023-06-07, 22:31 authored by G Piganeau, Adam Eyre-WalkerAdam Eyre-WalkerIn an attempt to resolve the controversy about whether recombination occurs in human mtDNA, we have analysed three recently published data sets of complete mtDNA sequences along with 10 RFLP data sets. We have analysed the relationship between linkage disequilibrium (LD) and distance between sites under a variety of conditions using two measures of LD, r2 and |D'|. We find that there is a negative correlation between r2 and distance in the majority of data sets, but no overall trend for |D'|. Five out of six mtDNA sequence data sets show an excess of homoplasy, but this could be due to either recombination or hypervariable sites. Two additional recombination detection methods used, Geneconv and Maximum Chi-Square, showed nonsignificant results. The overall significance of these findings is hard to quantify because of nonindependence, but our results suggest a lack of evidence for recombination in human mtDNA.
History
Publication status
- Published
Journal
HeredityISSN
0018-067XExternal DOI
Volume
92Page range
282-288Pages
7.0Department affiliated with
- Evolution, Behaviour and Environment Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC