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AMPA receptor GluR2, but not GluR1 subunit deletion impairs emotional response conditioning in mice
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posted on 2023-06-07, 22:28 authored by A N Mead, H V Morris, C I Dixon, S L Rulten, L V Mayne, D Zamanillo, D N StephensDeletions of gria1 or gria2 genes encoding alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic-acid-receptor subunits differ in their effects on appetitive conditioning. The authors investigated whether similar differences would occur in an aversive conditioning test. The ability of a discrete stimulus paired with footshock to subsequently inhibit food-maintained operant responding (conditioned emotional response) was examined in mice with deletions of gria1 or gria2 genes. Whereas gria1 knockout (KO) mice performed normally compared with wild-type (WT) controls, gria2 KO mice displayed no reduction in response rates when the shock-paired stimulus was presented. Nevertheless, gria2 KOs displayed evidence of freezing in a footshock-paired context, indicating that aversive learning could occur. In addition, gria1 KO mice showed some evidence of increased anxiety, and gria2 KOs showed reduced anxiety, in the elevated plus-maze. (PsycINFO Database Record (c) 2012 APA, all rights reserved)
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Publication status
- Published
Journal
Behavioral NeuroscienceISSN
0735-7044External DOI
Issue
2Volume
120Page range
241-8Pages
8.0Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2012-02-06Usage metrics
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