Mead, A N, Morris, H V, Dixon, C I, Rulten, S L, Mayne, L V, Zamanillo, D and Stephens, D N (2006) AMPA receptor GluR2, but not GluR1 subunit deletion impairs emotional response conditioning in mice. Behavioral Neuroscience, 120 (2). pp. 241-8. ISSN 0735-7044

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Abstract

Deletions of gria1 or gria2 genes encoding alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic-acid-receptor subunits differ in their effects on appetitive conditioning. The authors investigated whether similar differences would occur in an aversive conditioning test. The ability of a discrete stimulus paired with footshock to subsequently inhibit food-maintained operant responding (conditioned emotional response) was examined in mice with deletions of gria1 or gria2 genes. Whereas gria1 knockout (KO) mice performed normally compared with wild-type (WT) controls, gria2 KO mice displayed no reduction in response rates when the shock-paired stimulus was presented. Nevertheless, gria2 KOs displayed evidence of freezing in a footshock-paired context, indicating that aversive learning could occur. In addition, gria1 KO mice showed some evidence of increased anxiety, and gria2 KOs showed reduced anxiety, in the elevated plus-maze. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

Item Type:	Article
Schools and Departments:	School of Life Sciences > Biochemistry
Depositing User:	Stuart Rulten
Date Deposited:	06 Feb 2012 19:17
Last Modified:	28 Feb 2013 12:36
URI:	http://sro.sussex.ac.uk/id/eprint/19944

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