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Lima, I, Peck, M R, Rendón-Von Osten, J, Soares, A M V M, Guilhermino, L and Rotchell, J M (2008) Ras gene in marine mussels: A molecular level response to petrochemical exposure. Marine Pollution Bulletin, 56 (4). pp. 633-640. ISSN 0025-326X
Full text not available from this repository.Abstract
Mussels are susceptible to numerous toxicants and are often employed as bioindicators. This study investigated the status of the ras proto-oncogene in Mytilus galloprovincialis following petrochemical exposure. A M. galloprovincialis homologue of the vertebrate ras gene was isolated, showing conserved sequence in regions of functional importance and a high incidence of polymorphic variation. Mutational damage was investigated in mussels chronically exposed to the water-accommodated fraction of #4 fuel-oil (WAF), and in mussels collected along the NW coast of Portugal in sites with different levels of petrochemical contamination. A ras gene point mutation was identified in the codon 35 of one individual exposed to 12.5% WAF. No mutations were detected in mussels from the WAF control or environmental samples. This represents the first report of a ras gene mutation, experimentally-induced by petrochemical exposure, in an invertebrate species.
| Item Type: | Article |
|---|---|
| Schools and Departments: | School of Life Sciences > Evolution, Behaviour and Environment |
| Subjects: | Q Science |
| Depositing User: | Mika Peck |
| Date Deposited: | 06 Feb 2012 19:15 |
| Last Modified: | 26 Jun 2013 10:12 |
| URI: | http://sro.sussex.ac.uk/id/eprint/19795 |