Model studies for the synthesis of galbonolide B

Eshelby, James, Goessmann, Matthias, Parsons, Philip J, Pennicott, Lewis and Highton, Adrian (2005) Model studies for the synthesis of galbonolide B. Organic and Biomolecular Chemistry, 3 (16). pp. 2994-2997. ISSN 1477-0520

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The construction of the fourteen membered ring present in galbonolide B 1 is reported. The 10,11-diene system present in the southern portion of 1 has been constructed using an ester enolate rearrangement/ silicon mediated fragmentation cascade, whilst the macrocycle has been synthesised following a Johnson rearrangement/ mercury assisted ring closure protocol.

Item Type: Article
Additional Information: Synthetic work carried at Sussex and directed by the principle author PJP also involved, two industrial collaborators as co authors. A novel approach to the synthesis of galbonolide B.
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Philip Parsons
Date Deposited: 06 Feb 2012 19:08
Last Modified: 14 May 2012 15:43
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