Paradowski, Michael (2011) Synthesis of a novel octahydro pyrrolo[3,4-c] pyrrole cyclic amidine via 1,3-dipolar cycloaddition of azomethine ylides. Synlett (11). pp. 1543-1546. ISSN 09365214

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Abstract

A concise synthesis of fused bicyclic pyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides is reported. The exo cycloadduct isomer enables the synthesis of a novel cyclic amidine toward the preparation of a potential human histamine H4 receptor antagonist. The minor endo isomer led to the isolation of a new triazine ring through an intramolecular reductive cyclisation

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
Depositing User:	Michael Paradowski
Date Deposited:	06 Feb 2012 19:02
Last Modified:	31 May 2012 14:51
URI:	http://sro.sussex.ac.uk/id/eprint/19041

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