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Synthesis of a novel octahydro pyrrolo[3,4-c] pyrrole cyclic amidine via 1,3-dipolar cycloaddition of azomethine ylides

journal contribution
posted on 2023-06-07, 21:51 authored by Michael Paradowski
A concise synthesis of fused bicyclic pyrrolidines via 1,3-dipolar cycloaddition of azomethine ylides is reported. The exo cycloadduct isomer enables the synthesis of a novel cyclic amidine toward the preparation of a potential human histamine H4 receptor antagonist. The minor endo isomer led to the isolation of a new triazine ring through an intramolecular reductive cyclisation

History

Publication status

  • Published

Journal

Synlett

ISSN

09365214

Publisher

Thieme

Issue

11

Page range

1543-1546

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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