Planar-chiral imidazole-based phosphine ligands derived from [2.2]paracyclophane

Coles, Martyn P, Seacome, Richard J, Rowlands, Gareth J, Hitchcock, Peter B and Glover, Jean E (2010) Planar-chiral imidazole-based phosphine ligands derived from [2.2]paracyclophane. Dalton Transactions, 39 (15). pp. 3687-3694. ISSN 1477-9226

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Two planar chiral heteroaryl monophosphines have been synthesised and studied. The phosphines are readily prepared from 4-imidazole[2.2]paracyclophane by selective deprotonation and reaction with the appropriate dialkylchlorophosphines. The planar chiral imidazole was constructed in four steps from readily available [2.2]paracyclophane. The 2-phosphino-N-[2.2]paracyclophanes were active in the SuzukiMiyaura coupling of aryl bromides and chlorides. Coordination studies indicate P,N-chelation in the solid-state. These studies lay the foundations for asymmetric couplings

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Martyn Coles
Date Deposited: 06 Feb 2012 18:48
Last Modified: 19 Mar 2012 15:41
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