Eyre-Walker, Adam (2000) Do mitochondria recombine in humans? Philosophical Transactions B: Biological Sciences, 355 (1403). pp. 1573-1580. ISSN 1471-2970

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Abstract

Until very recently, mitochondria were thought to be clonally inherited through the maternal line in most higher animals. However, three papers published in 2000 claimed population-genetic evidence of recombination in human mitochondrial DNA. Here I review the current state of the debate. I review the evidence for the two main pathways by which recombination might occur: through paternal leakage and via a mitochondrial DNA sequence in the nuclear genome. There is no strong evidence for either pathway, although paternal leakage seems a definite possibility. However, the population-genetic evidence, although not conclusive, is strongly suggestive of recombination in mitochondrial DNA. The implications of non-clonality for our understanding of human and mitochondrial evolution are discussed

Item Type:	Article
Schools and Departments:	School of Life Sciences > Evolution, Behaviour and Environment
Depositing User:	Adam Eyre-Walker
Date Deposited:	06 Feb 2012 18:44
Last Modified:	17 May 2012 15:32
URI:	http://sro.sussex.ac.uk/id/eprint/18089

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