Lehmann, Alan R. (2002) Replication of damaged DNA in mammalian cells: new solutions to an old problem. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 509 (1-2). pp. 23-34. ISSN 0027-5107

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Abstract

All cells need not only to remove damage from their DNA, but also to be able to replicate DNA containing unrepaired damage. In mammalian cells, the major process by which cells are able to replicate damaged templates is translesion synthesis, the direct synthesis of DNA past altered bases. Crucial to this process is a series of recently discovered DNA polymerases. Most of them belong to a new family of polymerases designated the Y-family, which have conserved sequences in the catalytic N-terminal half of the proteins. These polymerases have different efficiencies and specificities in vitro depending on the type of damage in the template.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Sussex Centre for Genome Damage and Stability
Related URLs:	Organisation
Depositing User:	Alan Lehmann
Date Deposited:	06 Feb 2012 18:43
Last Modified:	23 Jul 2012 09:55
URI:	http://sro.sussex.ac.uk/id/eprint/17907

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