How do Rab proteins function in membrane traffic?

Armstrong, John (2000) How do Rab proteins function in membrane traffic? International Journal of Biochemistry and Cell Biology, 32 (3). pp. 303-307. ISSN 1357-2725

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The Rabs are a group of GTP-binding proteins implicated for some time in the targeting of different transport vesicles within the cell, but it has been unclear how they function, or how they relate to a second group of targeting proteins, the SNAREs. Recent work, discussed in this review, has used biophysical, biochemical and genetic approaches to begin to answer these questions for Rab3, Rab5 and the yeast protein Sec4p. However, the results from these three Rabs lead to a surprising conclusion: the different Rabs seem to function via highly diverse target proteins

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: John Armstrong
Date Deposited: 06 Feb 2012 18:42
Last Modified: 16 Jul 2012 09:48
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