Stanley, Mathew, Mayr, Juliane, Huber, Wolfgang, Vlasak, Reinhard and Streicher, Hansjorg (2011) Synthesis and Inhibitory Activity of Sialic Acid Derivatives Targeted at Viral Sialate-O- Acetylesterases. European Journal of Medicinal Chemistry, 46 (7). pp. 2852-2860. ISSN 0223-5234

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Abstract

A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
Depositing User:	Mathew Stanley
Date Deposited:	06 Feb 2012 18:40
Last Modified:	15 Jun 2012 08:45
URI:	http://sro.sussex.ac.uk/id/eprint/17714

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