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Synthesis and Inhibitory Activity of Sialic Acid Derivatives Targeted at Viral Sialate-O- Acetylesterases

journal contribution
posted on 2023-06-07, 20:56 authored by Mathew Stanley, Juliane Mayr, Wolfgang Huber, Reinhard Vlasak, Hansjorg Streicher
A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus.

History

Publication status

  • Published

Journal

European Journal of Medicinal Chemistry

ISSN

0223-5234

Publisher

Elsevier

Issue

7

Volume

46

Page range

2852-2860

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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