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Tonic regulation of satiety by 5-HT1B receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies

journal contribution
posted on 2023-06-07, 20:48 authored by Michelle D Lee, Elizabeth M Somerville, Guy A Kennett, Colin T Dourish, Pete CliftonPete Clifton
Activation of 5-HT1B receptors is thought to play an important role in the inhibitory influence of serotonin on feeding behaviour and body weight in mammals. Earlier studies have shown that 5-HT1B-knockout (KO) mice eat more and are heavier than wild-type (WT) controls and that the selective 5-HT1B receptor agonist CP-94,253 reduces food intake in food-deprived mice. Here we characterize the behavioural effects of both CP-94,253 and the selective 5-HT1B receptor antagonist SB224289 on feeding and other behaviours within the behavioural satiety sequence, and also report a c-fos mapping study using CP-94,253. CP-94,253 produced a dose-dependent suppression of food intake with a profile consistent with a selective effect on feeding behaviour. These effects were absent or reduced in 5-HT1B-KO mice and in WT mice pretreated with SB224289. SB224289 administered alone enhanced food intake consistent with impaired satiation; a similar effect was apparent in 5-HT1B-KO mice compared to WT. CP-94,253 induced c-fos in a range of structures previously implicated in the expression of feeding behaviour. These results suggest that the activation of 5-HT1B receptors is an important component of endogenous satiation mechanisms in the mouse.

History

Publication status

  • Published

Journal

European Journal of Neuroscience

ISSN

0953-816X

Issue

11

Volume

19

Page range

3017-3025

Pages

9.0

Department affiliated with

  • Neuroscience Publications

Notes

E.M.Somerville supervised the neuroanatomical work and analysed c-fos results. E.M.Somerville co-authored the paper in collaboration with P.G.Clifton and M.D.Lee. We have used an approach integrating a number of levels (neuroanatomy and behaviour) to increase understanding of the regulation of food intake in the mouse.

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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