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Structure and function of the Epstein-Barr virus transcription factor, EBNA 3C

journal contribution
posted on 2023-06-07, 20:34 authored by Michelle WestMichelle West
EBNA 3C is one of only nine proteins expressed by the tumourigenic ¿-herpesvirus Epstein-Barr virus (EBV) during the infection and immortalization of human B lymphocytes. In fact, the expression of EBNA 3C has been shown to be essential for the B-cell transformation process to take place. The mechanism by which EBNA 3C contributes to viral pathogenicity has therefore been the subject of intensive research over many years. The first clues on the function of EBNA 3C came from analysis of the primary amino acid sequence of EBNA 3C which identified a number of domains commonly found in transcriptional regulatory proteins. These domains include a proline-rich and a glutamine-proline-rich domain and a putative bZIP domain located in the N-terminus of the protein. EBNA 3C has subsequently been shown to function as a regulator of both viral and cellular transcription and to have potent effects on normal cell-cycle regulatory pathways. This review will discuss our current knowledge of the functions of EBNA 3C, the roles played by the different domains of EBNA 3C in these functions, and summarize some recent work from our laboratory that provides the first structural and functional analysis of the putative bZIP domain of EBNA 3C.

History

Publication status

  • Published

Journal

Current Protein and Peptide Science

ISSN

1389-2037

Publisher

Bentham Science Publishers

Issue

2

Volume

7

Page range

123-136

Pages

14.0

Department affiliated with

  • Biochemistry Publications

Research groups affiliated with

  • Haematology Research Group Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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