Alexeev, Dmitriy, Barlow, Paul N, Bury, Stella M, Charrier, Jean-Damien, Cooper, Alan, Hadfield, David, Jamieson, Craig, Kelly, Sharon M, Layfield, Robert, Mayer, R John, McSparron, Helen, Price, Nicholas C, Ramage, Robert, Sawyer, Lindsay, Starkmann, Bernard A, Uhrin, Dusan, Wilken, Jill and Young, Douglas W (2003) Synthesis, structural and biological studies of ubiquitin mutants containing (2S, 4S)-5-fluoroleucine residues strategically placed in the hydrophobic core. ChemBioChem, 4 (9). pp. 894-896. ISSN 1439-4227

Full text not available from this repository.

Item Type:	Article
Additional Information:	DWY is corresponding author and directed the synthetic work. The work reports the first ubiquitin variants in which selected leucine residues in the hydrophobic core have been replaced by (2S,4S)-5-fluoroleucine residues. Protein X-ray crystallographic, 19F-NMR and biophysical methods were used to show that protein folding was unafected.
Schools and Departments:	School of Life Sciences > Chemistry
Depositing User:	EPrints Services
Date Deposited:	06 Feb 2012 18:33
Last Modified:	25 May 2021 08:27
URI:	http://sro.sussex.ac.uk/id/eprint/17118

📧 Request an update