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The synthesis and reactivity of optically pure amino acids bearing side-chain thioamides

journal contribution
posted on 2023-06-07, 20:01 authored by John M Sanderson, P Singh, Colin W G Fishwick, John B C Findlay
The synthesis and reactivity of fully protected thioamide analogues of asparagine and glutamine are described. A key feature of the synthetic strategies employed was the ability to perform selective thiations on multiple carbonyl-containing substrates. Also described are the preparations of thioamide derivatives of phenylalanine. The utility of these amino acid derivatives for solid-phase peptide synthesis is discussed.

History

Publication status

  • Published

Journal

Journal of the Chemical Society, Perkin Transactions 1

ISSN

0300-922X

Publisher

RSC Publishing

Volume

19

Page range

3227 - 3231

ISBN

1470-4358

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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