University of Sussex
Browse

File(s) not publicly available

How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex.

journal contribution
posted on 2023-06-07, 19:46 authored by Alessandro BianchiAlessandro Bianchi, D Shore
The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at individual chromosome ends by the telomeric protein/DNA complex in a manner dependent on telomere repeat-array length. A dynamic interplay between telomerase-inhibiting factors bound at duplex DNA repeats and telomerase-promoting ones bound at single-stranded terminal DNA overhangs appears to modulate telomerase activity and to be directly related to the transient deprotection of telomeres. We discuss recent advances on the mechanism of telomerase regulation at chromosome ends in both yeast and mammalian systems.

History

Publication status

  • Published

Journal

Molecular Cell

ISSN

10972765

Publisher

Cell Press

Issue

2

Volume

31

Page range

153-165

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC