Jackson, Anne, Brown, Geraldine and Stephens, David N (1996) N-methyl-D-asparate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA) glutamate-receptor antagonist have different interactionswith discriminative stimuli of abused drugs. Psychopharmacology, 128 (3). pp. 320-327. ISSN 0033-3158

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Abstract

The effects of the AMPA-receptor antagonists NBQX and GYKI 52466 were compared with those of the NMDA-receptor channel blocker dizocilpine in two drug discrimination tests. In the first, rats were trained to discriminate morphine (2 mg/kg) from saline and in the second, to discriminate ketamine (7 mg/kg) from saline, using a two-lever food reinforced method. NBQX (1-6 mg/kg) did not substitute for either morphine or ketamine, even at a dose which reduced response rates (6 mg/kg). Likewise, the noncompetitive antagonist GYKI 52466 (5 and 10 mg/kg) produced only saline lever responding in the ketamine trained rats. When tested in combination with the training drug, NBQX (4.5 mg/kg) did not alter the morphine generalisation gradient, and similarly, neither NBQX (3 mg/kg) nor GYKI 52466 (5 and 10 mg/kg) interacted with the ketamine cue. In contrast, dizocilpine (0.05 mg/kg) significantly disrupted discrimination of morphine and produced clear drug lever responding (0.0125-0.1 mg/kg) in ketamine trained rats. These results suggest that AMPA-receptor antagonists and non-competitive NMDA-antagonists have different stimulus properties.

Item Type:	Article
Schools and Departments:	School of Psychology > Psychology
Depositing User:	Dai Stephens
Date Deposited:	06 Feb 2012 15:49
Last Modified:	28 Feb 2013 15:40
URI:	http://sro.sussex.ac.uk/id/eprint/14606

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