Crombag, Hans S and Shaham, Yavin (2002) Renewal of drug seeking by contextual cues after prolonged extinction in rats. Behavioral Neuroscience, 116 (1). pp. 169-173.

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Abstract

Contextual stimuli associated with drug exposure can modulate various effects of drugs, but little is known about their role in relapse to drug seeking. Using a renewal procedure, the authors report that drug-associated contextual stimuli play a critical role in relapse to drug-seeking previously maintained by a heroin-cocaine mixture (speedball). Rats were trained to self-administer speedball, after which drug-reinforced behavior was extinguished over 20 days in the self-administration context or in a different context. On the test day, rats exposed to the drug-associated context, after extinction in a different context, reliably renewed drug seeking. The authors suggest that the renewal procedure can be used to study mechanisms underlying relapse to drug seeking elicited by drug-associated contextual stimuli.

Item Type:	Article
Schools and Departments:	School of Psychology > Psychology
Depositing User:	Hans Crombag
Date Deposited:	06 Feb 2012 15:48
Last Modified:	16 Mar 2012 12:14
URI:	http://sro.sussex.ac.uk/id/eprint/14537

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