Mead, Andy N, Vasilaki, Anna, Spyraki, Christina, Duka, Theodora and Stephens, David N (1999) AMPA involvement in c-fos expression in prefrontal cortex and amygdala dissociates neural substrates of conditioned activity and conditioned reward. European Journal of Neuroscience, 11 (11). 4089¿4098.

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Abstract

Exposure to an environment, previously conditioned to amphetamine (1 mg/kg, i.p.), induced locomotor activity and c-fos expression (a marker for neuronal activation) in the mouse medial prefrontal cortex (mPFC) and amygdala; acute or repeated amphetamine (1 mg/kg, i.p.) administration induced c-fos expression additionally in the nucleus accumbens. An -amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(f)quinoxaline (NBQX), blocked expression of conditioned activity, and prevented the increase in c-fos expression in mPFC, implicating mPFC AMPAergic transmission in the conditioned component of behavioural sensitization to amphetamine. NBQX failed to block the expression of amphetamine-conditioned place preference, a measure of conditioned reward, or conditioned c-fos expression in the amygdala, an area implicated in the expression of conditioned place preference. These findings indicate that the conditioned components of behavioural sensitization depend on AMPA-receptor-mediated activation in mPFC, but that conditioned reward does not.

Item Type:	Article
Schools and Departments:	School of Psychology > Psychology
Depositing User:	Dora Duka
Date Deposited:	06 Feb 2012 15:46
Last Modified:	30 Nov 2012 16:58
URI:	http://sro.sussex.ac.uk/id/eprint/14372

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