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AMPA involvement in c-fos expression in prefrontal cortex and amygdala dissociates neural substrates of conditioned activity and conditioned reward
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posted on 2023-06-07, 18:41 authored by Andy N Mead, Anna Vasilaki, Christina Spyraki, Dora Duka, David N StephensExposure to an environment, previously conditioned to amphetamine (1 mg/kg, i.p.), induced locomotor activity and c-fos expression (a marker for neuronal activation) in the mouse medial prefrontal cortex (mPFC) and amygdala; acute or repeated amphetamine (1 mg/kg, i.p.) administration induced c-fos expression additionally in the nucleus accumbens. An -amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-receptor antagonist, 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(f)quinoxaline (NBQX), blocked expression of conditioned activity, and prevented the increase in c-fos expression in mPFC, implicating mPFC AMPAergic transmission in the conditioned component of behavioural sensitization to amphetamine. NBQX failed to block the expression of amphetamine-conditioned place preference, a measure of conditioned reward, or conditioned c-fos expression in the amygdala, an area implicated in the expression of conditioned place preference. These findings indicate that the conditioned components of behavioural sensitization depend on AMPA-receptor-mediated activation in mPFC, but that conditioned reward does not.
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Publication status
- Published
Journal
European Journal of NeurosciencePublisher
European Journal of NeuroscienceIssue
11Volume
11Page range
4089¿4098ISBN
0953-816xDepartment affiliated with
- Psychology Publications
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- No
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- Yes
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2012-02-06Usage metrics
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