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Deficits in sensory-specific devaluation task performance following genetic deletions of cannabinoid (CB1) receptor

journal contribution
posted on 2023-06-07, 18:30 authored by Hans CrombagHans Crombag, Alexander W Johnson, Anne M Zimmer, Andreas Zimmer, Peter C Holland
Cannabinoid CB1 receptor is abundantly expressed throughout the CNS and is implicated in numerous physiological and behavioral functions, including appetite and feeding. In the present study, wild-type and CB1 heterozygous and homozygous knockout mice were tested on an instrumental outcome-selective devaluation task to assess changes in acquired instrumental response levels for a distinct food reward following selective satiation. Deletion of CB1 receptor, as well as reduction in CB1 expression (HET), produced deficits in outcome-selective instrumental devaluation. These results identify a critical role for CB1 receptor in the ability of animals to represent, update, and/or use sensory-specific outcome representations to alter appetitive behaviors.

History

Publication status

  • Published

Journal

Learning and Memory

ISSN

1072-0502

Publisher

Cold Spring Harbor Laboratory Press

Issue

1

Volume

17

Page range

18-22

Pages

5.0

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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