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Xu, Hong-Ping, Furman, Moran, Mineur, Yann S, Chen, Hui, King, Sarah L, Zenisek, David, Zhou, Z Jimmy, Butts, Daniel A, Tian, Ning, Picciotto, Marina R and Crair, Michael C (2011) An instructive role for patterned spontaneous retinal activity in mouse visual map development. Neuron, 70 (6). pp. 1115-1127. ISSN 0896-6273
Full text not available from this repository.Abstract
Complex neural circuits in the mammalian brain develop through a combination of genetic instruction and activity-dependent refinement. The relative role of these factors and the form of neuronal activity responsible for circuit development is a matter of significant debate. In the mammalian visual system, retinal ganglion cell projections to the brain are mapped with respect to retinotopic location and eye of origin. We manipulated the pattern of spontaneous retinal waves present during development without changing overall activity levels through the transgenic expression of 2-nicotinic acetylcholine receptors in retinal ganglion cells of mice. We used this manipulation to demonstrate that spontaneous retinal activity is not just permissive, but instructive in the emergence of eye-specific segregation and retinotopic refinement in the mouse visual system. This suggests that specific patterns of spontaneous activity throughout the developing brain are essential in the emergence of specific and distinct patterns of neuronal connectivity.
| Item Type: | Article |
|---|---|
| Additional Information: | Generated the mice that were used for this study. Did all of the initial characterization of beta2 expression in transgenic mice. |
| Schools and Departments: | School of Psychology > Psychology |
| Related URLs: | |
| Depositing User: | Sarah King - Psychology |
| Date Deposited: | 06 Feb 2012 15:39 |
| Last Modified: | 30 Nov 2012 16:58 |
| URI: | http://sro.sussex.ac.uk/id/eprint/13715 |