Lee, Michelle, Somerville, Liz, Kennett, Guy A, Dourish, Colin Trevor and Clifton, Pete (2004) Tonic regulation of satiety by 5-HT1B receptors in the mouse: converging evidence from behavioural and c-fos immunoreactivity studies. European Journal of Neuroscience, 19 (11). pp. 3017-3025. ISSN 0953-816X

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Abstract

Activation of 5-HT1B receptors is thought to play an important role in the inhibitory influence of serotonin on feeding behaviour and body weight in mammals. Earlier studies have shown that 5-HT1B-knockout (KO) mice eat more and are heavier than wild-type (WT) controls and that the selective 5-HT1B receptor agonist CP-94,253 reduces food intake in food-deprived mice. Here we characterize the behavioural effects of both CP-94,253 and the selective 5-HT1B receptor antagonist SB224289 on feeding and other behaviours within the behavioural satiety sequence, and also report a c-fos mapping study using CP-94,253. CP-94,253 produced a dose-dependent suppression of food intake with a profile consistent with a selective effect on feeding behaviour. These effects were absent or reduced in 5-HT1B-KO mice and in WT mice pretreated with SB224289. SB224289 administered alone enhanced food intake consistent with impaired satiation; a similar effect was apparent in 5-HT1B-KO mice compared to WT. CP-94,253 induced c-fos in a range of structures previously implicated in the expression of feeding behaviour. These results suggest that the activation of 5-HT1B receptors is an important component of endogenous satiation mechanisms in the mouse.

Item Type:	Article
Additional Information:	Senior author; first author was research assistant on BBSRC LINK project grant for which Clifton was PI. Remaining authors were industrial collaborators and a colleague.
Schools and Departments:	School of Psychology > Psychology
Depositing User:	Liz Somerville
Date Deposited:	06 Feb 2012 15:36
Last Modified:	30 Nov 2012 16:58
URI:	http://sro.sussex.ac.uk/id/eprint/13534

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