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Aversive conditioning following repeated withdrawal from ethanol and epileptic kindling

journal contribution
posted on 2023-06-07, 18:00 authored by Tamzin Ripley, Geraldine Brown, Sarah J Dunworth, David N Stephens
Repeated withdrawal from ethanol, a procedure which resembles amygdala kindling in increasing seizure sensitivity, impairs the acquisition of fear conditioning (Stephens et al ., 2001, Eur. J. Neurosci., 14 , 2023-31). In contrast, rats previously kindled by repeated electrical stimulation of basolateral amygdala, or repeated administration of pentylenetetrazol, showed increased suppression of operant responding during the presentation of a stimulus conditioned to footshock when conditioning took place several weeks following the kindling experience. Neither form of kindling nor repeated ethanol withdrawal altered taste aversion conditioning, though rats treated chronically with ethanol and given a single withdrawal experience showed enhanced taste aversion conditioning. These results suggest that, despite evidence suggesting a common neuronal mechanism underlying seizure sensitivity following these types of kindling, they differ in their effects on fear conditioning.

History

Publication status

  • Published

Journal

European Journal of Neuroscience

ISSN

0953-816X

Issue

8

Volume

17

Page range

1664-1670

Pages

7.0

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2012-02-06

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