KARAPANAGIOTIDIS_Cerebral_Cortex_AUG_2022.pdf (722.08 kB)
Physical distance to sensory-motor landmarks predicts language function
journal contribution
posted on 2023-06-10, 07:12 authored by Xiuyi Wang, Katya Krieger-Redwood, Meichao Zhang, Zaixu Cui, Xiaokang Wang, Theodoros KarapanagiotidisTheodoros Karapanagiotidis, Yi Du, Robert Leech, Boris C Bernhardt, Daniel S Margulies, Jonathan Smallwood, Elizabeth JefferiesAuditory language comprehension recruits cortical regions that are both close to sensory-motor landmarks (supporting auditory and motor features) and far from these landmarks (supporting word meaning). We investigated whether the responsiveness of these regions in task-based functional MRI is related to individual differences in their physical distance to primary sensorimotor landmarks. Parcels in the auditory network, that were equally responsive across story and math tasks, showed stronger activation in individuals who had less distance between these parcels and transverse temporal sulcus, in line with the predictions of the "tethering hypothesis," which suggests that greater proximity to input regions might increase the fidelity of sensory processing. Conversely, language and default mode parcels, which were more active for the story task, showed positive correlations between individual differences in activation and sensory-motor distance from primary sensory-motor landmarks, consistent with the view that physical separation from sensory-motor inputs supports aspects of cognition that draw on semantic memory. These results demonstrate that distance from sensorimotor regions provides an organizing principle of functional differentiation within the cortex. The relationship between activation and geodesic distance to sensory-motor landmarks is in opposite directions for cortical regions that are proximal to the heteromodal (DMN and language network) and unimodal ends of the principal gradient of intrinsic connectivity.
History
Publication status
- Published
File Version
- Published version
Journal
Cerebral CortexISSN
1047-3211Publisher
Oxford University PressExternal DOI
Issue
8Volume
33Page range
4305-4318Event location
United StatesDepartment affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2023-05-31First Open Access (FOA) Date
2023-05-31First Compliant Deposit (FCD) Date
2023-05-31Usage metrics
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