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Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex

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posted on 2023-06-10, 07:10 authored by Thomas E Cope, Ediz SohogluEdiz Sohoglu, Katie A Peterson, P Simon Jones, Catarina Rua, Luca Passamonti, William Sedley, Brechtje Post, Jan Coebergh, Christopher R Butler, Peter Garrard, Khaled Abdel-Aziz, Masud Husain, Timothy D Griffiths, Karalyn Patterson, Matthew H Davis, James B Rowe
Humans use predictions to improve speech perception, especially in noisy environments. Here we use 7-T functional MRI (fMRI) to decode brain representations of written phonological predictions and degraded speech signals in healthy humans and people with selective frontal neurodegeneration (non-fluent variant primary progressive aphasia [nfvPPA]). Multivariate analyses of item-specific patterns of neural activation indicate dissimilar representations of verified and violated predictions in left inferior frontal gyrus, suggestive of processing by distinct neural populations. In contrast, precentral gyrus represents a combination of phonological information and weighted prediction error. In the presence of intact temporal cortex, frontal neurodegeneration results in inflexible predictions. This manifests neurally as a failure to suppress incorrect predictions in anterior superior temporal gyrus and reduced stability of phonological representations in precentral gyrus. We propose a tripartite speech perception network in which inferior frontal gyrus supports prediction reconciliation in echoic memory, and precentral gyrus invokes a motor model to instantiate and refine perceptual predictions for speech.

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Publication status

  • Published

File Version

  • Published version

Journal

Cell Reports

ISSN

2211-1247

Publisher

Elsevier BV

Issue

5

Volume

42

Page range

a112422 1-24

Event location

United States

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2023-05-25

First Open Access (FOA) Date

2023-05-25

First Compliant Deposit (FCD) Date

2023-05-25

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