1-s2.0-S2211124723004333-main.pdf (5.92 MB)
Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex
journal contribution
posted on 2023-06-10, 07:10 authored by Thomas E Cope, Ediz SohogluEdiz Sohoglu, Katie A Peterson, P Simon Jones, Catarina Rua, Luca Passamonti, William Sedley, Brechtje Post, Jan Coebergh, Christopher R Butler, Peter Garrard, Khaled Abdel-Aziz, Masud Husain, Timothy D Griffiths, Karalyn Patterson, Matthew H Davis, James B RoweHumans use predictions to improve speech perception, especially in noisy environments. Here we use 7-T functional MRI (fMRI) to decode brain representations of written phonological predictions and degraded speech signals in healthy humans and people with selective frontal neurodegeneration (non-fluent variant primary progressive aphasia [nfvPPA]). Multivariate analyses of item-specific patterns of neural activation indicate dissimilar representations of verified and violated predictions in left inferior frontal gyrus, suggestive of processing by distinct neural populations. In contrast, precentral gyrus represents a combination of phonological information and weighted prediction error. In the presence of intact temporal cortex, frontal neurodegeneration results in inflexible predictions. This manifests neurally as a failure to suppress incorrect predictions in anterior superior temporal gyrus and reduced stability of phonological representations in precentral gyrus. We propose a tripartite speech perception network in which inferior frontal gyrus supports prediction reconciliation in echoic memory, and precentral gyrus invokes a motor model to instantiate and refine perceptual predictions for speech.
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Publication status
- Published
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- Published version
Journal
Cell ReportsISSN
2211-1247Publisher
Elsevier BVExternal DOI
Issue
5Volume
42Page range
a112422 1-24Event location
United StatesDepartment affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2023-05-25First Open Access (FOA) Date
2023-05-25First Compliant Deposit (FCD) Date
2023-05-25Usage metrics
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