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Radiation induced DNA damage responses

journal contribution
posted on 2023-06-07, 13:57 authored by Penny Jeggo, Markus Löbrich
The amazing feature of ionising radiation (IR) as a DNA damaging agent is the range of lesions it induces. Such lesions include base damage, single strand breaks (SSBs), double strand breaks (DSBs) of varying complexity and DNA cross links. A range of DNA damage response mechanisms operate to help maintain genomic stability in the face of such damage. Such mechanisms include pathways of DNA repair and signal transduction mechanisms. Increasing evidence suggests that these pathways operate co-operatively. In addition, the relative impact of one mechanism over another most probably depends upon the cell cycle phase and tissue type. Here, the distinct damage response pathways are reviewed and the current understanding of the interplay between them is considered. Since DNA DSBs are the major lethal lesion induced by IR, the focus lies in the mechanisms responding to direct or indirectly induced DSBs.

History

Publication status

  • Published

Journal

Radiation Protection Dosimetry

ISSN

1742-3406

Publisher

Radiation Protection Dosimetry

Issue

1-4

Volume

122

Page range

124-127

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Notes

GDSC181

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2007-05-03

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