Hancock, Fran, Rosas, Fernando E, Mediano, Pedro A M, Luppi, Andrea I, Cabral, Joanna, Dipasquale, Ottavia and Turkheimer, Federico E (2022) May the 4C's be with you: an overview of complexity-inspired frameworks for analysing resting-state neuroimaging data. Journal of the Royal Society Interface, 19 (191). pp. 1-14. ISSN 1742-5689

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Abstract

Competing and complementary models of resting-state brain dynamics contribute to our phenomenological and mechanistic understanding of whole-brain coordination and communication, and provide potential evidence for differential brain functioning associated with normal and pathological behaviour. These neuroscientific theories stem from the perspectives of physics, engineering, mathematics and psychology and create a complicated landscape of domain-specific terminology and meaning, which, when used outside of that domain, may lead to incorrect assumptions and conclusions within the neuroscience community. Here, we review and clarify the key concepts of connectivity, computation, criticality and coherence-the 4C's-and outline a potential role for metastability as a common denominator across these propositions. We analyse and synthesize whole-brain neuroimaging research, examined through functional magnetic imaging, to demonstrate that complexity science offers a principled and integrated approach to describe, and potentially understand, macroscale spontaneous brain functioning.

Item Type:	Article
Keywords:	complexity, computation, connectivity, criticality, integrated information, metastability, Brain, Head, Neuroimaging, Neurosciences, Physics
Schools and Departments:	School of Engineering and Informatics > Informatics
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	02 Mar 2023 11:09
Last Modified:	02 Mar 2023 11:15
URI:	http://sro.sussex.ac.uk/id/eprint/111004

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