The human papillomavirus oncoproteins a review of the host pathways targeted on the road to transformation. .pdf (4.1 MB)
The human papillomavirus oncoproteins: a review of the host pathways targeted on the road to transformation
journal contribution
posted on 2023-06-10, 05:58 authored by James A Scarth, Molly R Patterson, Ethan MorganEthan Morgan, Andrew MacdonaldPersistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in over 99?% of cervical cancer cases, and a significant proportion of oropharyngeal and anogenital cancers. The key drivers of HPV-mediated transformation are the oncoproteins E5, E6 and E7. Together, they act to prolong cell-cycle progression, delay differentiation and inhibit apoptosis in the host keratinocyte cell in order to generate an environment permissive for viral replication. The oncoproteins also have key roles in mediating evasion of the host immune response, enabling infection to persist. Moreover, prolonged infection within the cellular environment established by the HR-HPV oncoproteins can lead to the acquisition of host genetic mutations, eventually culminating in transformation to malignancy. In this review, we outline the many ways in which the HR-HPV oncoproteins manipulate the host cellular environment, focusing on how these activities can contribute to carcinogenesis.
History
Publication status
- Published
File Version
- Published version
Journal
Journal of General VirologyISSN
0022-1317Publisher
Microbiology SocietyExternal DOI
Issue
3Volume
102Page range
e001540 1-28Event location
EnglandDepartment affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2023-01-13First Open Access (FOA) Date
2023-01-13First Compliant Deposit (FCD) Date
2023-01-12Usage metrics
Categories
No categories selectedKeywords
HPVcancerkeratinocyteoncoproteinsignallingAlphapapillomavirusApoptosisCarcinogenesisCell Cycle CheckpointsCell DifferentiationCell ProliferationCell TransformationViralCellular ReprogrammingEpigenesisGeneticGenomeHumansImmune EvasionOncogene ProteinsPDZ DomainsPapillomavirus InfectionsRNAUntranslatedSignal TransductionVirus Replication
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC