Agnarelli, Alessandro, Vella, Viviana, Samuels, Mark, Papanastasopoulos, Panagiotis and Giamas, Georgios (2022) Incorporating immunotherapy in the management of gastric cancer: molecular and clinical implications. Cancers, 14 (18). e4378 1-25. ISSN 2072-6694

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Abstract

Gastric cancer has a median survival of 11 months, and this poor prognosis has not improved over the last 30 years. Recent pre-clinical data suggest that there is high tumour-related neoantigen expression in gastric cancer cells, suggesting that a clinical strategy that enhances the host’s immune system against cancer cells may be a successful approach to improve clinical outcomes. Additionally, there has been an increasing amount of translational evidence highlighting the relevance of PD-L1 expression in gastric cancer cells, indicating that PD-1/PD-L1 inhibitors may be useful. Several molecular subgroups of gastric cancer have been identified to respond with excellent outcomes to immunotherapy, including microsatellite instable tumours, tumours bearing a high tumour mutational burden, and tumours related to a chronic EBV infection. In gastric cancer, immunotherapy has produced durable responses in chemo-refractory patients; however, most recently there has been a lot of enthusiasm as several large-scale clinical trials highlight the improved survival noted from the incorporation of immunotherapy in the first line setting for advanced gastric cancer. Our review aims to discuss current pre-clinical and clinical data supporting the innovative role of immunotherapy in gastric cancer.

Item Type:	Article
Keywords:	EBV, H. pylori, PD-L1, gastric cancer, immune microenvironment, immunotherapy
Schools and Departments:	School of Life Sciences > Biochemistry
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	12 Jan 2023 11:42
Last Modified:	12 Jan 2023 11:45
URI:	http://sro.sussex.ac.uk/id/eprint/110096

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