Association_between_inflammatory_biomarker.5.pdf (195.01 kB)
Association between inflammatory biomarker profiles and cardiovascular risk in individuals with and without HIV
journal contribution
posted on 2023-06-10, 05:50 authored by Luxsena Sukumaran, Ken M Kunisaki, Nicholas Bakewell, Alan Winston, Patrick WG Mallon, Nicki Doyle, Jane Anderson, Marta Boffito, Lewis Haddow, Frank A Post, Jaime Vera RojasJaime Vera Rojas, Memory Sachikonye, Caroline A SabinBackground: People with HIV have an increased risk for cardiovascular morbidity and mortality. Inflammation and immune activation may contribute to this excess risk. Methods: We assessed thirty-one biomarkers in a subset of POPPY participants and identified three distinct inflammatory profiles: ‘gut/immune activation’, ‘neurovascular’, and ‘reference’ (relatively low levels of inflammation). Ten-year CVD risk predictions were calculated using the QRISK, Framingham Risk Score (FRS) and the Data Collection on Adverse effects of anti-HIV Drugs (D:A:D) algorithms. The distributions of CVD risk scores across the different inflammatory profiles, stratified by HIV status, were compared using median quantile regression. Results: Of the 312 participants included (70% living with HIV, median [interquartile range; IQR] age 55 [51–60] years; 82% male; 91% white), 146, 36, and 130 were in the ‘gut/immune activation’, ‘neurovascular’, and ‘reference’ cluster, respectively. The median [IQR] QRISK scores were 9.3% (4.5–14.5) and 10.2% (5.5–16.9) for people with and without HV, respectively, with similar scores obtained with the FRS and D:A:D. We observed statistically significant differences between the distributions of scores in the three clusters among people with HV. In particular, median QRISK (5.8% [1.0–10.7] and 3.1% [0.3–5.8]) scores were higher, respectively, for those in the ‘gut/immune activation’ and ‘neurovascular’ clusters compared to those in the reference cluster. Conclusions: People with HIV with increased gut/immune activation have a higher CVD risk compared to those with relatively low inflammation. Our findings highlight that clinically important inflammatory subgroups could be useful to differentiate risk and maximise prediction of CVD among people with HIV.
History
Publication status
- Published
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- Published version
Journal
AIDSISSN
0269-9370Publisher
Ovid Technologies (Wolters Kluwer Health)External DOI
Issue
4Volume
37Page range
595-603Event location
EnglandDepartment affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2023-01-05First Open Access (FOA) Date
2023-01-05First Compliant Deposit (FCD) Date
2023-01-05Usage metrics
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