fonc-12-975644.pdf (3.83 MB)
Pro-tumorigenic role of type 2 diabetes-induced cellular senescence in colorectal cancer
journal contribution
posted on 2023-06-10, 05:32 authored by Francesco Melia, Palita Udomjarumanee, Dmitry Zinovkin, Nahid Arghiani, Md Zahidul I PranjolColorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. The disease still remains incurable and highly lethal in the advanced stage, representing a global health concern. Therefore, it is essential to understand the causes and risk factors leading to its development. Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. In this review, we will discuss the mechanisms according to which T2D induces cellular senescence and the role of type 2 diabetes-induced cellular senescence in the pathogenesis and progression of colorectal cancer. Lastly, we will explore the current therapeutic approaches and challenges in targeting senescence.
History
Publication status
- Published
File Version
- Published version
Journal
Frontiers in OncologyISSN
2234-943XPublisher
Frontiers Media SAExternal DOI
Volume
12Page range
a975644 1-20Event location
SwitzerlandDepartment affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-11-23First Open Access (FOA) Date
2022-11-23First Compliant Deposit (FCD) Date
2022-11-22Usage metrics
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