Alruwais_BBB_APOE_2022.pdf (1.57 MB)
Evidence of emerging BBB changes in mid-age apolipoprotein E epsilon-4 carriers
journal contribution
posted on 2023-06-10, 05:31 authored by Nourah M Alruwais, Jenifer M Rusted, Naji TabetNaji Tabet, Nicholas DowellNicholas DowellIntroduction Studies have recognized that the loss of the blood–brain barrier (BBB) integrity is a major structural biomarker where neurodegenerative disease potentially begins. Using a combination of high-quality neuroimaging techniques, we investigated potential subtle differences in BBB permeability in mid-age healthy people, comparing carriers of the apolipoprotein E epsilon-4 (APOEe4) genotype, the biggest risk factor for late onset, non-familial AD (LOAD) with APOEe3 carriers, the population norm. Methods Forty-one cognitively healthy mid-age participants (42–59) were genotyped and pseudo-randomly selected to participate in the study by a third party. Blind to genotype, all participants had a structural brain scan acquisition including gadolinium-based dynamic contrast-enhanced magnetic resonance imaging acquired using a T1-weighted 3D vibe sequence. A B1 map and T1 map were acquired as part of the multi-parametric mapping acquisition. Results Non-significant, but subtle differences in blood–brain barrier permeability were identified between healthy mid-age APOEe4 and APOEe3 carriers, matched on age, education, and gender. Discussion This study demonstrated a tendency toward BBB permeability in APOEe4 participants emerging from mid-age, with quantitative differences observable on a number of the measures. While the differences did not reach a statistical significance, the results from this study hint at early changes in e4 carrier BBB that may help identify at-risk populations and facilitate the development of early interventions to change the trajectory of decline.
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Publication status
- Published
File Version
- Published version
Journal
Brain and BehaviorISSN
2162-3279Publisher
WileyExternal DOI
Page range
e2806 1-11Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-11-22First Open Access (FOA) Date
2022-11-22First Compliant Deposit (FCD) Date
2022-11-21Usage metrics
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