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Diurnal changes in the efficiency of information transmission at a sensory synapse.pdf (2.67 MB)

Diurnal changes in the efficiency of information transmission at a sensory synapse

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posted on 2023-06-10, 05:30 authored by Jose Moya DiazJose Moya Diaz, Ben James, Federico Esposti, Jamie Johnston, Leon LagnadoLeon Lagnado
Neuromodulators adapt sensory circuits to changes in the external world or the animal’s internal state and synapses are key control sites for such plasticity. Less clear is how neuromodulation alters the amount of information transmitted through the circuit. We investigated this question in the context of the diurnal regulation of visual processing in the retina of zebrafish, focusing on ribbon synapses of bipolar cells. We demonstrate that contrast-sensitivity peaks in the afternoon accompanied by a four-fold increase in the average Shannon information transmitted from an active zone. This increase reflects higher synaptic gain, lower spontaneous “noise” and reduced variability of evoked responses. Simultaneously, an increase in the probability of multivesicular events with larger information content increases the efficiency of transmission (bits per vesicle) by factors of 1.5-2.7. This study demonstrates the multiplicity of mechanisms by which a neuromodulator can adjust the synaptic transfer of sensory information.

History

Publication status

  • Published

File Version

  • Published version

Journal

Nature Communications

ISSN

2041-1723

Publisher

Springer Science and Business Media LLC

Volume

13

Page range

2613 1-15

Event location

England

Department affiliated with

  • Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-11-21

First Open Access (FOA) Date

2022-11-21

First Compliant Deposit (FCD) Date

2022-11-21

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