Diurnal changes in the efficiency of information transmission at a sensory synapse.pdf (2.67 MB)
Diurnal changes in the efficiency of information transmission at a sensory synapse
journal contribution
posted on 2023-06-10, 05:30 authored by Jose Moya DiazJose Moya Diaz, Ben James, Federico Esposti, Jamie Johnston, Leon LagnadoLeon LagnadoNeuromodulators adapt sensory circuits to changes in the external world or the animal’s internal state and synapses are key control sites for such plasticity. Less clear is how neuromodulation alters the amount of information transmitted through the circuit. We investigated this question in the context of the diurnal regulation of visual processing in the retina of zebrafish, focusing on ribbon synapses of bipolar cells. We demonstrate that contrast-sensitivity peaks in the afternoon accompanied by a four-fold increase in the average Shannon information transmitted from an active zone. This increase reflects higher synaptic gain, lower spontaneous “noise” and reduced variability of evoked responses. Simultaneously, an increase in the probability of multivesicular events with larger information content increases the efficiency of transmission (bits per vesicle) by factors of 1.5-2.7. This study demonstrates the multiplicity of mechanisms by which a neuromodulator can adjust the synaptic transfer of sensory information.
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Publication status
- Published
File Version
- Published version
Journal
Nature CommunicationsISSN
2041-1723Publisher
Springer Science and Business Media LLCExternal DOI
Volume
13Page range
2613 1-15Event location
EnglandDepartment affiliated with
- Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-11-21First Open Access (FOA) Date
2022-11-21First Compliant Deposit (FCD) Date
2022-11-21Usage metrics
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