Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer.pdf (1.87 MB)
Development of a novel nanoemulgel formulation containing cumin essential oil as skin permeation enhancer
journal contribution
posted on 2023-06-10, 05:20 authored by Katayoun Morteza-Semnani, Majid Saeedi, Jafar Akbari, Mohammad Eghbali, Amirhossein Babaei, Seyyed M H Hashemi, Ali NokhodchiEssential oils have been proposed as promising non-toxic transdermal permeation enhancers. Their use is limited because of their low water solubility. The use of nanotechnology-based strategies is one of the ways to overcome this limitation. This study aimed to explore the transdermal permeation enhancing capability of cumin essential oil in nanoemulgel systems containing diclofenac sodium. Cumin essential oil nanoemulsion was produced by high-pressure homogenization technique. The formulation was optimized by changing HLB values in a range of 9.65–16.7 using different surfactant mixtures, namely, Tween 20, Tween 80, and Span 80. Preparations were characterized by polydispersity index, droplet size, and zeta potential. Nanoemulsion with concentrations of 2 and 4% essential oil was incorporated into 0.75% Carbopol gel matrix to make nanoemulgel formulation, and its permeation enhancing effect was performed through Franz diffusion cells. Antinociceptive activities of the formulations were measured in thermal (tail-flick) and chemical (formalin) models of nociception in mice. Characterization exhibited that at HLB value of 9.65, the smallest particle size (82.20 ± 5.82 nm) was formed. By increasing the essential oil percentage in the nanoemulgel from 1 to 2%, the permeation of diclofenac increased from 28.39 ± 1.23 to 34.75 ± 1.07 µg/cm2 at 24 h. The value of permeation from the simple gel (21.18 ± 2.51 µg/cm2) and the marketed product (22.97 ± 1.92 µg/cm2) was lower than the formulations containing essential oil. Nanoemulgel of diclofenac containing essential oil showed stronger antinociceptive effects in formalin and tail-flick tests than simple diclofenac gel and marketed formulation. In conclusion, the study proved that nanoemulgel formulation containing cumin essential oil could be considered as a promising skin enhancer to enhance the therapeutic effect of drugs. Graphical abstract: [Figure not available: see fulltext.].
History
Publication status
- Published
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- Published version
Journal
Drug Delivery and Translational ResearchISSN
2190-393XPublisher
Springer Science and Business Media LLCExternal DOI
Volume
12Page range
1455-1465Event location
United StatesDepartment affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-11-03First Open Access (FOA) Date
2022-11-03First Compliant Deposit (FCD) Date
2022-11-03Usage metrics
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