Preferential Cochleotoxicity of Cisplatin.pdf (1.07 MB)
Preferential Cochleotoxicity of Cisplatin
journal contribution
posted on 2023-06-10, 05:19 authored by Pattarawadee Prayuenyong, David M Baguley, Corne Kros, Peter SteygerCisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has been consistently reported in the current literature. Inner ear hair cells seem to have intrinsic characteristics that make them susceptible to direct exposure to cisplatin. The existing literature suggests, however, that cisplatin might have different patterns of drug trafficking across the blood-labyrinth-barrier, or different degrees of cisplatin uptake to the hair cells in the cochlear and vestibular compartments. This review proposes an explanation for the preferential cochleotoxicity of cisplatin based on current evidence as well as the anatomy and physiology of the inner ear. The endocochlear potential, generated by the stria vascularis, acting as the driving force for hair cell mechanoelectrical transduction might also augment cisplatin entry into cochlear hair cells. Better understanding of the stria vascularis might shed new light on cochleotoxic mechanisms and inform the development of otoprotective interventions to moderate cisplatin associated ototoxicity.
History
Publication status
- Published
File Version
- Published version
Journal
Frontiers in NeuroscienceISSN
1662-4548Publisher
Frontiers Media SAExternal DOI
Volume
15Page range
a695268 1-8Event location
SwitzerlandDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-11-03First Open Access (FOA) Date
2022-11-03First Compliant Deposit (FCD) Date
2022-11-03Usage metrics
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