Association between NMDAR availability and glutamate levels_presubmission_final.pdf (401.13 kB)
The association between N-methyl-d-aspartate receptor availability and glutamate levels: A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls
journal contribution
posted on 2023-06-10, 05:16 authored by Katherine Beck, Atheeshaan Arumuham, Stefan Brugger, Robert A McCutcheon, Mattia Veronese, Barbara Santangelo, Colm J McGinnity, Joel Dunn, Stephen Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, Teresa Sementa, Radhouene Neji, Sameer Jauhar, Franklin Aigbirhio, Istvan Boros, Federico Turkheimer, Alexander Hammers, David Lythgoe, James StoneJames Stone, Oliver D HowesBackground: Evidence from post-mortem studies and in vivo imaging studies suggests there may be reduced N-methyl-d-aspartate receptor (NMDAR) levels in the hippocampus in patients with schizophrenia. Other studies have reported increased glutamate in striatum in schizophrenia patients. It has been hypothesised that NMDAR hypofunction leads to the disinhibition of glutamatergic signalling; however, this has not been tested in vivo. Methods: In this study, we investigated the relationship between hippocampal NMDAR and striatal glutamate using simultaneous positron emission tomography-magnetic resonance (PET-MR) imaging. We recruited 40 volunteers to this cross-sectional study; 21 patients with schizophrenia, all in their first episode of illness, and 19 healthy controls. We measured hippocampal NMDAR availability using the PET ligand [18F]GE179. This was indexed relative to whole brain as the distribution volume ratio (DVR). Striatal glutamatergic indices (glutamate and Glx) were acquired simultaneously, using combined PET-MR proton magnetic resonance spectroscopy (1H-MRS). Results: A total of 33 individuals (15 healthy controls, 18 patients) were included in the analyses (mean (SD) age of controls, 27.31 (4.68) years; mean (SD) age of patients, 24.75 (4.33), 27 male and 6 female). We found an inverse relationship between hippocampal DVR and striatal glutamate levels in people with first-episode psychosis (rho?=?-0.74, p?
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of PsychopharmacologyISSN
0269-8811Publisher
SAGE PublicationsExternal DOI
Issue
9Volume
36Page range
1051-1060Event location
United StatesDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-10-28First Open Access (FOA) Date
2022-10-28First Compliant Deposit (FCD) Date
2022-10-28Usage metrics
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