Synthesis of a thiazole library via an iridium-catalyzed sulfur ylide insertion reaction : Sussex Research Online

Tools

Hassell-Hart, Storm, Speranzini, Elisa, Srikwanjai, Sirihathai, Hossack, Euan, Roe, S Mark, Fearon, Daren, Akinbosede, Daniel, Hare, Stephen and Spencer, John (2022) Synthesis of a thiazole library via an iridium-catalyzed sulfur ylide insertion reaction. Organic Letters. ISSN 1523-7060

PDF - Published Version
Available under License Creative Commons Attribution.
Download (793kB)

Official URL: https://doi.org/10.1021/acs.orglett.2c02996

Abstract

A library of thiazoles and selenothiazoles were synthesized via Ir-catalyzed ylide insertion chemistry. This process is a functional group, particularly heterocycle-substituent tolerant. This was applied to the synthesis of fanetizole, an anti-inflammatory drug, and a thiazole-containing drug fragment that binds to the peptidyl-tRNA hydrolase (Pth) in Neisseria gonorrheae bacteria.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
SWORD Depositor:	Mx Elements Account
Depositing User:	Mx Elements Account
Date Deposited:	21 Oct 2022 11:02
Last Modified:	21 Oct 2022 11:15
URI:	http://sro.sussex.ac.uk/id/eprint/108603

View download statistics for this item

📧 Request an update