The opioid system in depression

Jelen, Luke A, Stone, James M, Young, Allan H and Mehta, Mitul A (2022) The opioid system in depression. Neuroscience and Biobehavioral Reviews, 140. a104800 1-17. ISSN 0149-7634

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Opioid receptors are widely distributed throughout the brain and play an essential role in modulating aspects of human mood, reward, and well-being. Accumulating evidence indicates the endogenous opioid system is dysregulated in depression and that pharmacological modulators of mu, delta, and kappa opioid receptors hold potential for the treatment of depression. Here we review animal and clinical data, highlighting evidence to support: dysregulation of the opioid system in depression, evidence for opioidergic modulation of behavioural processes and brain regions associated with depression, and evidence for opioidergic modulation in antidepressant responses. We evaluate clinical trials that have examined the safety and efficacy of opioidergic agents in depression and consider how the opioid system may be involved in the effects of other treatments, including ketamine, that are currently understood to exert antidepressant effects through non-opioidergic actions. Finally, we explore key neurochemical and molecular mechanisms underlying the potential therapeutic effects of opioid system engagement, that together provides a rationale for further investigation into this relevant target in the treatment of depression.

Item Type: Article
Keywords: Delta opioid receptor (DOR), Depression, Kappa opioid receptor (KOR), Mu opioid receptor (MOR), Nociceptin opioid receptor (NOP), Opioid system, Analgesics, Opioid, Animals, Antidepressive Agents, Depression, Humans, Receptors, Opioid, Receptors, Opioid, kappa, Receptors, Opioid,
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 03 Oct 2022 09:32
Last Modified: 03 Oct 2022 09:45

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