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The opioid system in depression
journal contribution
posted on 2023-06-10, 04:58 authored by Luke A Jelen, James StoneJames Stone, Allan H Young, Mitul A MehtaOpioid receptors are widely distributed throughout the brain and play an essential role in modulating aspects of human mood, reward, and well-being. Accumulating evidence indicates the endogenous opioid system is dysregulated in depression and that pharmacological modulators of mu, delta, and kappa opioid receptors hold potential for the treatment of depression. Here we review animal and clinical data, highlighting evidence to support: dysregulation of the opioid system in depression, evidence for opioidergic modulation of behavioural processes and brain regions associated with depression, and evidence for opioidergic modulation in antidepressant responses. We evaluate clinical trials that have examined the safety and efficacy of opioidergic agents in depression and consider how the opioid system may be involved in the effects of other treatments, including ketamine, that are currently understood to exert antidepressant effects through non-opioidergic actions. Finally, we explore key neurochemical and molecular mechanisms underlying the potential therapeutic effects of opioid system engagement, that together provides a rationale for further investigation into this relevant target in the treatment of depression.
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Publication status
- Published
File Version
- Published version
Journal
Neuroscience and Biobehavioral ReviewsISSN
0149-7634Publisher
Elsevier BVExternal DOI
Volume
140Page range
a104800 1-17Event location
United StatesDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-10-03First Open Access (FOA) Date
2022-10-03First Compliant Deposit (FCD) Date
2022-09-30Usage metrics
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