Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis

Gifford, George, Crossley, Nicholas, Morgan, Sarah, Kempton, Matthew J, Dazzan, Paola, Modinos, Gemma, Azis, Matilda, Samson, Carly, Bonoldi, Ilaria, Quinn, Beverly, Smart, Sophie E, Antoniades, Mathilde, Bossong, Mattijis G, Broome, Matthew R, Perez, Jesus, Howes, Oliver D, Stone, James M, Allen, Paul, Grace, Anthony A and McGuire, Philip (2021) Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis. Human Brain Mapping, 42 (2). pp. 439-451. ISSN 1065-9471

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)


The ability to identify biomarkers of psychosis risk is essential in defining effective preventive measures to potentially circumvent the transition to psychosis. Using samples of people at clinical high risk for psychosis (CHR) and Healthy controls (HC) who were administered a task fMRI paradigm, we used a framework for labelling time windows of fMRI scans as ‘integrated’ FC networks to provide a granular representation of functional connectivity (FC). Periods of integration were defined using the ‘cartographic profile’ of time windows and k-means clustering, and sub-network discovery was carried out using Network Based Statistics (NBS). There were no network differences between CHR and HC groups. Within the CHR group, using integrated FC networks, we identified a sub-network negatively associated with longitudinal changes in the severity of psychotic symptoms. This sub-network comprised brain areas implicated in bottom-up sensory processing and in integration with motor control, suggesting it may be related to the demands of the fMRI task. These data suggest that extracting integrated FC networks may be useful in the investigation of biomarkers of psychosis risk.

Item Type: Article
Keywords: cartographic profile, clinical high-risk for psychosis, network analysis, network based statistics, network integration, task fMRI, Adolescent, Adult, Brain, Connectome, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Nerve Net, Predictive Value of Tests, Prodromal Symptoms, Psychomotor Performance, Psychotic Disorders, Risk Factors, Young Adult
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 03 Oct 2022 14:41
Last Modified: 03 Oct 2022 14:45

View download statistics for this item

📧 Request an update